G U I D E L I N E S

There are several guidelines for genotoxicity. Listed below are the guidelines which have included the comet assay for genotoxicity evaluation.

Committee on mutagenecity of chemical in food, consumer products and the environment (COM): Guidance on a strategy for testing of chemicals for mutagenecity, U.K.

IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans
Albertini et al - Mutation Research 463:111–172 (2000).

Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing
Tice et al  - Environmental and Molecular Mutagenesis 35:206–221 (2000).

Recommendations for conducting the in vivo alkaline Comet assay
Hartmann et al - Mutagenesis 18(1):45–51 (2003).

A review on the current status of short term tests:

Current status of short term tests for evaluation of genotoxicity, mutagenicity and carcinogenicity of environmental chemicals and NCEs.

Bajpayee et al - Toxicology Mechanisms and Methods 15: 1-26 (2005).

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